Exploring the effects of polls on public opinion: How and when media reports of policy preferences can become self-fulfilling prophesies

Recent work has suggested that media reporting about the public’s policy preferences may be self-reinforcing, contributing to greater policy conformity.This article presents additional evidence in support of this theory and adds new detail about the conditionality of these effects.Results from two experiments are described in which respondents ar

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Single-cell RNA sequencing uncovers molecular mechanisms of intravenous immunoglobulin plus methylprednisolone in Kawasaki disease: attenuated monocyte-driven inflammation and improved NK cell cytotoxicity

IntroductionIntravenous immunoglobulin (IVIG) plus methylprednisolone as initial intensive therapy or additional therapy in Kawasaki disease (KD) has been used in clinical practice.However, its molecular and cellular mechanism is unclear.MethodsWe performed single-cell analysis on 14 peripheral blood mononuclear cell (PBMC) samples obtained from 7

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Partial p53 reactivation is sufficient to induce cancer regression

Abstract Background Impaired p53 function is one of the central molecular features of a tumor cell and even a partial reduction in p53 activity can increase the cancer risk in mice and men.From a therapeutic perspective it is noteworthy that tumor cells often become addicted to the absence of p53 providing a rationale for developing p53 reactivatin

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